引用本文:李靖宇,程景民,贺培凤,田玥,于琦.基于文献挖掘视角的组学研究脉络梳理[J].中华医学图书情报杂志,2018,27(3):44-49.
基于文献挖掘视角的组学研究脉络梳理
Literature mining-based summarization of studies on omics
DOI:10.3969/j.issn.1671-3982.2018.03.009
中文关键词:  组学  文献挖掘  共现分析  可视化
英文关键词:Omics  Literature mining  Co-occurrence analysis  Visualization
基金项目:国家自然科学基金面上项目“基于多元分析的科研文献微观实体评价理论与实证研究——以生物医学为例”(71573162)
作者单位
李靖宇 山西医科大学管理学院山西 太原030001 
程景民 山西医科大学管理学院山西 太原030001 
贺培凤 山西医科大学管理学院山西 太原030001 
田玥 山西医科大学管理学院山西 太原030001 
于琦 山西医科大学管理学院山西 太原030001 
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中文摘要:
      目的:梳理组学研究脉络,分析组学研究热点趋势,帮助科研工作者把握研究方向,为科研管理部门在组学研究方面的资助提供决策支持。方法:利用E-utilities下载1986-2016年PubMed数据库收录的含有“-Omics/Omic/Omes/Ome”的题录信息27 040 819条,在题录信息的题目和摘要中对以“-Omics/Omic/Omes/Ome”结尾的词进行标注、筛选,并利用词频分析法、共现分析法、社会网络分析法对筛选结果进行分析。结果:获得组学相关记录共346 977条,文献发表量逐年递增,自2000年后呈井喷式增长。各类单一组学的文献发表量均呈逐年递增的趋势,其中基因组学文献发表量最多。2014年之后,转录组学的文献发表量赶超了蛋白质组学,成为继基因组学之后的第二大组学类型。转录组学、线粒体基因组学与基因组学共现的文献量在某一时间节点后呈井喷式增长,其余组学类型与基因组学共现的文献量都稳定增长。结论:后基因组时代把组学研究推向了高潮,无论是数量还是种类都出现了井喷式的增长。多类型组学的融合研究越来越受科研人员的关注。
英文摘要:
      Objective To analyze the hotspots and trend in studies on omics in order to help scientific researchers to keep their research direction and scientific management departments in deciding their fund support for the studies on omics.Methods A total of 27 040 819 papers with their titles containing -omics/omic/omes/ome covered in PubMed from 1986 to 2016 were downloaded using E-utilities. The words with a suffix of -omics/omic/omes/ome in the titles and abstracts of these papers were tagged. The picked out words were analyzed by word frequency analysis, co-occurrence analysis and social network analysis, respectively.Results A total of 346 977 words containing -omics/omic/omes/ome were picked out from the 27 040 819 papers. The number of published papers increased progressively year after year and has been increasing in a blowout way since 2000. The number of published papers on each omics tended to increase year by year with genomics ranked first followed by transcriptome because the number of published papers on it has been more than that on proteomics since 2014.The co-occurrence of words with a suffix of -omics/omic/omes/ome with a suffix of -omics/omic/omes/ome in the published papers on transcriptome, mitochondrial genomics and genomics increased in a blowout way at a certain time point while a stable increase was found in that of the other omics and genomics.Conclusion The post genome era has pushed the studies on genomics to a new high tide with a blowout increase both in their number and in their types. Collaborative studies on multiomics have attracted the attention of more and more scientific researchers.
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